So Young Choi

Postdoctoral Researcher | Nanomaterials & Bioengineering
Seoul, KR.

About

Highly accomplished Postdoctoral Researcher with a Ph.D. in Chemistry, specializing in innovative nanobiosensor development, DNA-mediated nanostructure programming, and advanced drug delivery systems. Leverages expertise in in vitro and in vivo experimentation to drive groundbreaking research, evidenced by a robust publication record and contributions to cutting-edge bioengineering solutions.

Work

Korea Institute of Science and Technology (KIST)
|

Postdoctoral Researcher

Seoul, Seoul, Korea (Republic of)

Summary

Leading innovative research at KIST, specializing in biomaterials and nanobiosensors to advance gene delivery and disease diagnosis strategies.

Highlights

Spearheaded the development of vitreous-mimetic liposomes, enabling effective gene delivery to the eye via intravitreal injection and opening new avenues for ocular therapeutics.

Investigated lysosomal targeting of liposomes with acidic pH and cathepsin B, successfully demonstrating induced protein aggregate clearance and publishing findings in *Cell communication and signaling*.

Contributed to the design and application of DNA-mediated dynamically reconfigurable plasmonic gold nanostructures, advancing capabilities in biological computing and nanobiosensing, published in *Small methods*.

Developed a novel cell-interface-deciphering lipid nanotablet for nanoparticle logic gate-based real-time single-cell analysis, resulting in a publication in *Nano Letters*.

Leveraged advanced technical skills including NUPACK for DNA design, plasmonic nanoparticle synthesis, and Python for image processing to execute complex experimental designs and data analysis.

Education

Seoul National University
Seoul, Seoul, Korea (Republic of)

Ph.D.

Chemistry

Courses

Thesis: Programming Plasmonic Nanoparticle Interactions with DNA Reaction Pathways for Biological Computing and Nanobiosensor

Hanyang University
Seoul, Seoul, Korea (Republic of)

B.S.

Chemistry

Awards

Postdoctoral Fellowship

Awarded By

Korea Foundation for Woman in Science, Engineering and Technology (WISET)

Awarded a prestigious fellowship to support advanced postdoctoral research in scientific and engineering fields.

Lecture & Research Scholarship

Awarded By

Seoul National University

Recognized for outstanding academic performance and research potential with a scholarship supporting lecture and research activities.

Academic Excellence Award

Awarded By

Hanyang University

Received for consistently high academic achievement during undergraduate studies in 2017.

Academic Excellence Award

Awarded By

Hanyang University

Received for consistently high academic achievement during undergraduate studies in 2016.

Alumni-Supported Scholarship

Awarded By

Department of Chemistry, Hanyang University

Granted a scholarship funded by alumni, recognizing academic merit and potential in chemistry.

Publications

Vitreous-mimetic liposomes enable effective gene delivery to the eye via intravitreal injection

Published by

Submitted

Summary

So Young Choi†, Chang Sik Cho†, Seongchan Kim⁺, Hyunkyung Kim⁺, Ki Hun Kim*, Donghyun Jo* and Hyojin Lee*, "Vitreous-mimetic liposomes enable effective gene delivery to the eye via intravitreal injection", submitted.

Lysosomal targeting of liposomes with acidic pH and cathepsin B induces protein aggregate clearance

Published by

Cell communication and signaling

Summary

Minsol Jeon, Daeun Kim, So Young Choi, Seoyoung Kim, Seongchan Kim, Hyojin Lee*, Hyunkyung Kim*, "Lysosomal targeting of liposomes with acidic pH and cathepsin B induces protein aggregate clearance", Cell communication and signaling, 23, 296 (2025).

Design, Mechanisms, and Applications of DNA-Mediated Dynamically Reconfigurable Plasmonic Gold Nanostructures

Published by

Small methods

Summary

So Young Choi, Jieun Kim⁺¹, Eunho Song†, Eunhye Park, Jingrui Wu, Juyeon Yoo, Jwa-Min Nam *, “Design, Mechanisms, and Applications of DNA-Mediated Dynamically Reconfigurable Plasmonic Gold Nanostructures”, Small methods, 2500448 (2025).

Cell-Interface-Deciphering Lipid Nanotablet for Nanoparticle Logic Gate-Based Real-Time Single-Cell Analysis

Published by

Nano Letters

Summary

So Young Choi, Young Suk Yu, Eunhye Park, Sung Hee Baek and Jwa-Min Nam*, “Cell-Interface-Deciphering Lipid Nanotablet for Nanoparticle Logic Gate-Based Real-Time Single-Cell Analysis”, Nano Letters, 25, 7, 2725–2731 (2025).

Nanotechnologies for the Diagnosis and Treatment of SARS-CoV-2 and Its Variants

Published by

Small Methods

Summary

Eunhye Park, So Young Choi⁺, Jieun Kim⁺, Niko Hildebrandt*, Jin Seok Lee*, Jwa-Min Nam*, "Nanotechnologies for the Diagnosis and Treatment of SARS-CoV-2 and Its Variants", Small Methods, 7, 2300034 (2023).

Nanoparticle-based computing architecture for nanoparticle neural networks

Published by

Science Advances

Summary

Sungi Kim, Namjun Kim, Jinyoung Seo, Jeong-Eun Park, Eun Ho Song, So Young Choi, Jieun Kim, Seungsang Cha, Ha H Park, Jwa-Min Nam*, "Nanoparticle-based computing architecture for nanoparticle neural networks.", Science Advances, 6, eabb3348 (2020).

Skills

Research Techniques

DNA design, NUPACK, Plasmonic nanoparticle synthesis, Liposome synthesis, Supported lipid bilayer synthesis, In vitro experimentation, In vivo experimentation, Image processing, Python.

Research Areas

Programmable nanomaterials, Nanobiosensors, Nanobiocomputing, Drug delivery, Immunosynapse.

Projects

TMZ-Encapsulating Liposomes for Glioblastoma Treatment via Intra-Cisterna Magna Delivery

Summary

Poster presentation on a novel approach for glioblastoma treatment using TMZ-encapsulating liposomes delivered via intra-cisterna magna.

Cell-Interfaced Lipid Nanotablet for multiplexed cellular membrane protein analysis

Summary

Poster presentation detailing a cell-interfaced lipid nanotablet for advanced analysis of cellular membrane proteins.